Specimen temperature control

The Integra Ti has a unique temperature control system – accurate to 0.1ºC.  Separate channels control the central stage insert and two additional areas, for extra Petri dishes.

Controlled by a touch screen, you can be confident of the most accurate temperature control available today.

Heated glass insert

In addition to the standard metal heated insert, the Integra Ti  has the option of an RI or Tokai Hit heated glass insert. Using the latest ITO technology, heat is evenly  distributed over the entire surface of the Petri dish, eliminating the central cold spot.

Stage movement

The Integra Ti  uses a built-in XY mechanical stage for manipulation of the Petri dish.

Syringes

The Integra Ti comes with two syringes included as standard. We offer both air and oil syringes with this system. Our very popular SAS air syringes give superb control and eliminate the need for oil.  Our new SOS oil syringe is now available with a quick fill feature to reduce set-up time.

Pipette location

The toolholders provide the simplest and quickest method ever for setting-up micropipettes. The toolholders, when used with a special objective and spacer (supplied), allow the micropipettes to be set-up 14mm above the Petri dish and then rapidly lowered to the desired position, preventing micropipette damage. The toolholders also have a special angular adjustment which allows the user to adjust the angle of the pipette with a single control without moving the tip of the pipette. Unique to RI, this feature makes it easy to ensure that the micropipette is slightly “toe-down” during sperm immobilisation and horizontal during sperm injection. This reduces the damage caused to the oocyte and therefore increases its chances of survival and hence development. For PGD, RI has developed a unique double toolholder which offers independent movement of both micropipettes.

Micromanipulators

Movement of the micropipettes is provided by RI’s exceptional TDU5000 micromanipulators, offering the most accurate and precise positioning available. Each micromanipulator offers both fine and coarse ZYX control and comes with our latest range of toolholders. The TDU5000s are extremely reliable and rarely require servicing. Being purely mechanical they do not suffer from delay as in electronic micromanipulators or lost motion and drift common in hydraulic systems.

  Integra Ti brochure (507.7 KiB, 1,106 hits)

  Integra Ti EU Declaration of Conformity (69.4 KiB, 489 hits)

London Women’s Clinic, U.K.

“Until recently, London Women’s Clinic have been using a variety of different micromanipulation systems, namely Narishige and older models from Research Instruments. We are now upgrading these to the latest Integra Ti systems from Research Instruments. Since the installation of the Integra Ti systems, we have noticed a significant rise in our success rates. We primarily believe that this is due to the highly developed design of the Integra Ti that allows our Embryologists to perform ICSI at the quickest times possible. All controls are simple to use and perfectly positioned. The pipette set-up is particularly rapid, allowing injection pipettes to be replaced within seconds during the ICSI procedure, very useful if a pipette becomes blocked during an ICSI. Overall, the features of the system mean that the specimen are kept out of the incubator for the shortest time possible, optimising our fertilisation rates. The other features of the Integra Ti such as the built-in heated plates and a digital help menu, which are not offered by other systems, are also of particular use.”

Matey Andonov

Ljubljana, Slovenia

“I have been doing ICSI since 2001 and having previously used the Narishige micromanipulators we have upgraded our ICSI system to the Integra Ti from Research Instruments. To be honest in the beginning there was difficulty, in changing systems the routine was gone and new steps had to be learned with perfection. But after the initial troubles, which would arise certainly with every other change in such a delicate procedure as ICSI, the micromanipulation became fantasy. With every ICSI the work was easier and quicker not to mention changing different types or brands of micropipettes, with adjustable angle of the pipette holder this step became really quick and accurate. We have found the unique features of the Integra Ti very useful in everyday routine and research work. From it’s touch screen controlled built in heated stages to the incredibly quick pipette set-up, the system excels at giving me the ability to control the micropipettes with great speed and accuracy. With this system I can now complete ICSI’s at a much quicker rate than ever before. This means that the cells are now out of the incubator for the shortest time possible giving the Embryos a better chance for survival and development.”

Cedomir Joksimovic

Q: What are the advantages of the Integra Ti over Narishige and Eppendorf?

A: The Integra Ti gives the user a natural movement with no delays from hydraulics or motors.

It has a much quicker and easier pipette set-up procedure with instant angle changer.

It is more compact and gives more lab space, whilst providing a larger stage surface area to work on.

Three accurate, built-in, heated stage inserts to provide stable temperature during micromanipulation with Glass insert option.

Air syringes are supplied as standard giving excellent control.

RI provides excellent technical support for repairs and servicing of equipment, which Narishige, as part of the Company Policy, do not.

It is mechanical in design, and by its very nature, has a reliability and longevity far-surpassing any electrical or hydraulic equipment.

Q: How easy is it to change over to RI if I’ve never used it before?

A: Very easy – most people convert perfectly after a couple of sessions. You have to get used to the new positions that your hands need to be in and get used to the control of the air syringes, but it takes very little time and once mastered, the control is superb and the operation much quicker.

Q: What if we don’t wish to use the air syringes?

A: We can supply our own high quality oil syringes, and we have even been able to incorporate the customers existing syringes into the Integra Ti system.

Q: Can RI provide training?

A: We can show how to use the equipment on installation, or we can arrange a training session either at a current users’ lab, or get an experienced embryologist to your lab at your cost.

Q: Is there anything that the Integra Ti can’t do that the others can?

A: The RI system does not have an x-axis lock that other systems use for injection. However, after they start to use the Integra Ti, all our customers find that an x-lock is unnecessary as they can inject perfectly without it.

Q: What comes with the system?

A: The Integra Ti comes as standard with:

Integra Stage Unit

Toolholders with Automatic pipette set-up

3 x Heated stage inserts

Coarse and fine micromanipulators

2 x Syringes / Injectors

2 x Hand-rests

x-y mechanical stage

Digital Help Menu

Optional extras:

Glass heated stage insert

Double tool-holder

Extra-smooth air syringe

Microscope

Camera

PC / monitor

Q: Which microscopes will it fit to?

A: Olympus IMT2, IX50/70, IX51/71

Nikon TMD, Diaphot 200/300, Eclipse TE200/300, Eclipse TE2000

Zeiss Axiovert 100, 135, 40, 200, Axio Observer

Leica DMIRB/DMIRE, DMI3000B/4000B/6000B

Q: How does it compare in price?

A: The Integra Ti is normally much better value for money than the Eppendorf system and competitive with the Narishige system, although will sometimes be more expensive. However, remember that you’re getting the syringes, 3 x heated inserts, the x-y mechanical stage and the automatic pipette set-up included which sometimes don’t appear on competitors’ quotes, and you can also have the reassurance that RI care about their customers and understand the often urgent needs of the IVF Industry. Also, you’re getting equipment that is mechanical in design, and by its very nature, has a longevity far-surpassing any electrical or hydraulic equipment.